In vitro modeling of atherosclerosis pathology by tissue engineering to develop novel pharmacological treatments.
Atherosclerosis is a dramatic burden in the current challenges of the Modern Medicine. The process leading to the accumulation of white blood cells, lipids and activated smooth muscle cells can interest several body regions, as the coronary arterial tree, the brain circulatory system and the peripheral vessels in the inferior limbs with poor consequences, as stroke and myocardial infarction. In this project,we aim at creating an in vitro human model of atherosclerosis based on decellularized arterial scaffoldsand vascular progenitors derived from the differentiation of induced pluripotent stem cells. This platform will be used for disease study, as well as to evaluate the therapeutic efficacy of novel pharmacologic compounds and/or discover new treatment targets
Gino Gerosa is Full Professor of Cardiac Surgery at the University of Padova Medical School. He performed the first Italian robot enhanced coronary bypass on beating heart. He led the team who performed the first Italian ABO incompatible heart transplant in pediatric patients and he performed the first Italian Cardiowest total artificial heart implant. He is currently Chief of Cardiac Surgery and Director of Heart Transplant Program at the UniversityHospitalof Padova.He serves asScientificDirector of CORIS, a consortiumdedicated to support research. He is author ofaround 390articles published on international journals.
Laura Iop is Assistant Professor of Applied Medical Technologiesat the University of Padova Medical School. Graduated in Medical Biotechnologies at the University of Padua (Italy) in 2005, Laura Iop earned the PhD in Cardiovascular Sciences at the same University in 2010, by focusing on stem cell-based treatments for myocardial infarction and heart valve tissue engineering. From 2010 to 2012, she performed a post-doctoral research on cardiac disease modeling with patient-specific induced pluripotent stem cells in the group of Molecular Cardiology at the Technical University of Munich (Germany). From 2012, she is Scientific responsible of the Cardiovascular Regenerative Medicine Group, directed by Prof. Gino Gerosa, at the University of Padua. She is author of about 35articles published on international journals
Tiago Fortunato is a post-doctoral researcher at the Cardiovascular Regenerative Medicine group, currently developing an in vitroatherosclerosis model by tissue engineering (WP1) based on decellularized arteries. He received his training as a biomedical scientist at University of Algarve (Portugal) in 2009, afterwards moving to UK where he obtained a master degree in tissue engineering from Cardiff University and a PhD from University of Bath in 2015 under the supervision of Dr. Giordano Pula and Dr. Paul de Bank. During this last period, his work was mainly focused on the subject of endothelial progenitors and biomaterials for cardiovascular implants. From2016 to 2018, he was a post-doctoral researcher at the Eindhoven University of Technology, working on the developmentof non-biodegradable electrospun vascular grafts for hemodialysis access. During his career, he published several research articles with particular emphasis on angiogenesis and tissue engineering