WP12

Tissue-engineered esophageal patch (TEEP)

The reconstruction of the upper alimentary tract after the treatment of esophageal pathologies such as caustic lesions, atresia, perforations and tumors, often requires the use of other organs as substitutes (usually stomach or colon) that are transposed or self-implanted in a different anatomical site.These complex surgical techniques are burdened by high morbidity and mortality even if the long term functional results are sub-optimal.Tissue engineering is proving to be an interesting promise for the development of tissue or organ substitutes, such as the esophagus, that can overcome the current limits of surgery; in fact, clinical applications in urology and cardiac have already been described.Based on these considerations, this project aims to develop an esophageal substitute with tissue engineering techniques and to develop implantation techniques for a clinical application.

 

TEAM

Prof. Stefano Merigliano

Specialist in General Surgery. Full Professor of General Surgery. Director of the Surgical Clinic 3 of the University of Padua. President of the School of Medicine of the University of Padua. He is the holder of the teaching of General Surgery II. Teacher of surgical techniques at the Specialization Schools in General Surgery, Thoracic Surgery and Vascular Surgery of the University of Padua. He has over4,000 general surgery, esophagus, stomach and colon surgery and proctology with both traditional and laparoscopic techniques.

Dott. Michele Valmasoni

Specialist in General Surgery and Doctor of Philosophyin Surgical Sciences and Technological Applications, Medical Director at the Hospital of Padua. He is dedicated to Epatobiliopancreatic Surgery and Transplantation and to EsophagealSurgery. He deals with general surgery and oncological surgery of the esophagus and stomach, hepatobiliopancreatic surgery and laparoscopic surgery. He has over 2000 major surgery operations. He is a contract professor and tutor at the School of Specialization in General Surgery and Professor at the Doctoral School in Clinical and Experimental Medical Sciences of the University of Padua. He is a fellow of the American College of Surgeon and a member of many national and international scientific societies, including the International Society for the Diseases of Esophagus (ISDE) and the Society for Surgery of the Alimentary Tract (SSAT). He is a reviewer for several international scientific journals.

Prof. Mario Costantini

Born in 1955, he graduated in Medicine and Surgery in Padua in 1980 with honors. Specialized in Padua in General Surgery (1985) and in Gastroenterology (1989), he has always been involved in diagnostics and minimally invasive therapy of esophageal-gastric functional diseases. In 1991-92 he was a Research Fellow at the University of Southern California, Los Angeles (Prof. T.R. DeMeester). He is currently responsible for the Simple Unit of Esophagus-Gastric Physiopathology and the Laboratory of Digestive Physiopathology attached to the Surgical Clinic III of the University -Hospital of Padua.

Dott. Renato Salvador

Graduated in Medicine and Surgery at the University of Padua in 2005. He specialized in General Surgery in Padua with honors; he has always dealt with esophageal-gastric diseases. He is currently a researcher at the University of Padua.In 2007-2008 he was an Esophageal Research Fellow at the University of Rochester Medical Center, Rochester NY, USA (prof. J. H. Peters). He is a member of many national and international scientific societies. including the International Society for the Diseases of Esophagus (ISDE) and the Society for Surgery of the Alimentary Tract (SSAT). He is a reviewer for several international scientific journals.Member of SICPRE (Italian Society of Plastic Reconstructive and Aesthetic Surgery), SICM (Italian Society of Hand Surgery) and EACA (European Society of Clinical Anatomy); member of the Centre for Mechanics of Biological Materials (CMBM) at the University of Padova. Speaker in International and National Scientific Congresses.

Dott.ssa Elisa Sefora Pierobon

Specialist in General Surgery and Research Doctor, Medical Director at the Hospital of Padua. She graduated in Medicine and Surgery and specialized in General Surgery in Padua. He received his PhD in Clinical and Experimental Sciences in 2018 in Padua. It is dedicated to Kidney and Pancreatic Transplantation Surgery and to Esophageal Surgery. In 2013-2014 she was Visiting Physician at the Center for Hepatobiliary Surgery and Multivisceral Transplantation at Mount Sinai Hospital in New York.She was Medical Director at the General Surgery with Thoracic Activity of the Ca ’Foncello Hospital in Treviso and is currently Medical Director at the University of Padua Hospital.

 

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