Hybrid membrane (HYME) for the construction of novel pulsatile chamber.
WP5 aims at creating a newly designed HYbrid MEmbrane (HYME) to coat the blood-contacting surface of the pulsatile chamber of the mechanical circulatory support to: 1) improve hemocompatibility; 2) reduce the risk of bleeding and thromboembolic complications; 3) prevent life-long anticoagulation.
The HYME will be created by coupling a thin polymeric layer with a decellularized bovine/porcine pericardial patch. The polymeric layer will be responsible for the mechanical resistance; the biological layer will be in direct contact with blood.
Andrea Bagno is Associate Professor of Industrial Bioengineering at the Faculty of Engineering, University of Padova. After the degree in Chemical Engineering (1991), he had the PhD in Chemical Engineering in 1995. Research interests focused on the interaction between biomaterials and biological tissue, and on biomaterial surface treatment and characterization. Other research activities concern: the biomechanical characterization of native and decellularized pericardium for the production of biological heart valves; the early detection of mechanical heart valves failure by phonocardiographic means; the assessment of skin microcirculation by means of Laser Doppler Fluxmetry.
Martina Todesco received the B.Sc. degree in Biomedical Engineering and the M.S. degree in Bioengineering from the University of Padova, in 2015 and 2018, respectively. She is currently research fellow at the University of Padova, Department of Industrial Engineering.
She performed her M.S. thesis as a fellow at IRRIV (International Renal Research Institute of Vicenza), the focus of the research was about blood-material interaction and the characterization of purification efficiency of a hemodialyzer for the continuous renal replacement therapy.
Carlo Zardin obtained the B.Sc. degree in Biomedical Engineering (2018) and the M.S. degree in Bioengineering (2020) at the University of Padova. His main expertise concerns mechanical tests on biological tissue and biomaterials. His experience was developed during his master thesis focusing on the realization and characterization of a hemocompatible material to produce mechanical support devices. Presently, he has a fellowship under the WP5 aimed at developing and testing a novel pulsatile chamber.